부산대학교 도서관

Oral sustained release gastroretentive dosage forms offer many advantages for drugs having absorption from upper gastrointestinal tract and improve the bioavailability of medications that are characterized by narrow absorption window. Microspheres were prepared by solvent evaporation technique consisting of Cefpodoxime proxetil (API), calcium silicate (FLR) as porous carrier and Ethyl Cellulose and HPMC K4M as rate controlling polymer. Box Behnken statistical screening designwas applied for optimization of formulation. The effect of various formulation and process variables on the particle morphology, entrapment efficiency, in vitro floating behaviour and in vitro drug release were studied. The percentage yield of all the formulation was found to be 71 - 85. The percentage entrapment efficiency was varied from 79 - 91%. The release rate was determined in simulated gastric fluids. The formulation demonstrated favourablein vitro floating and release characteristics. Multiple regression analysis was applied for study of the effect of independent variables on the dependent variables. Hence developed floating microspheres could be a promising delivery system for Cefpodoxime Proxetil with sustained release and improved bioavailability. [ABSTRACT FROM AUTHOR]