학술논문

Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges.
Document Type
Article
Source
International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13547. 19p.
Subject
*EXTRACELLULAR vesicles
*LIVER transplantation
*GRAFT rejection
*CELL communication
*IMMUNOREGULATION
Language
ISSN
1661-6596
Abstract
Extracellular vesicles (EVs) are emerging as a promising field of research in liver disease. EVs are small, membrane-bound vesicles that contain various bioactive molecules, such as proteins, lipids, and nucleic acids and are involved in intercellular communication. They have been implicated in numerous physiological and pathological processes, including immune modulation and tissue repair, which make their use appealing in liver transplantation (LT). This review summarizes the current state of knowledge regarding the role of EVs in LT, including their potential use as biomarkers and therapeutic agents and their role in graft rejection. By providing a comprehensive insight into this emerging topic, this research lays the groundwork for the potential application of EVs in LT. [ABSTRACT FROM AUTHOR]