학술논문
Mortality Following Blood Culture in Premature Infants: Increased with Gram-negative Bacteremia and Candidemia, but Not Gram-positive Bacteremia.
Document Type
Article
Author
Source
Subject
*NOSOCOMIAL infections
*GRAM-negative bacterial diseases
*NEONATAL infections
*PREMATURE infant diseases
*BACTERIAL diseases
*MORTALITY
PREMATURE infant death
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Language
ISSN
0743-8346
Abstract
OBJECTIVE:: To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture. STUDY DESIGN:: Multicenter cohort study of premature infants. RESULTS:: First blood culture was negative for 4648/5497 (78%) of the neonates - 390/4648 (8%) died prior to discharge. Mortality prior to discharge was 19% in the 161 infants with Gram-negative rod (GNR) bacteremia, 8% in the 854 neonates with coagulase negative staphylococcus (CONS), 6% in the 169 infants infected with other Gram-positive bacteria (GP-o), and 26% in the 115 neonates with candidemia. The excess 7-day mortality was 0% for Gram-positive organisms and 83% for GNR bacteremia and candidemia. Using negative blood culture as referent, GNR [hazard ratio (HR)=2.61] and candidemia (HR=2.27) were associated with increased mortality; CONS (HR=1.08) and GP-o (HR=0.97) were not. CONCLUSIONS:: Nosocomial GNR bacteremia and candidemia were associated with increased mortality but Gram-positive bacteremia was not.Journal of Perinatology (2004) 24, 175-180. doi:10.1038/sj.jp.7211068 Published online 26 February 2004 [ABSTRACT FROM AUTHOR]