학술논문
Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes.
Document Type
Article
Author
Custódio, Solange Vega; Piccoli, Raphaela Cassol; Goularte, Kelen Cristiane Machado; Simões, William Sanabria; de Mello, Julia Eisenhardt; de Souza, Anita Avila; de Mattos Almeida, Isabella Pompeu; Barschak, Alethéa Gatto; Tavares, Rejane Giacomelli; Stefanello, Francieli Moro; de Aguiar, Mayara Sandrielly Soares; Spanevello, Roselia Maria
Source
Subject
Language
ISSN
1028-415X
Abstract
This study evaluated the effects of Rubus sp. extract on behavioral and neurochemical parameters in female mice submitted to experimental model of depression induced by lipopolysaccharide (LPS). The results indicated that Rubus sp. extract protected against depressive-like behavior induced by LPS. Moreover, the administration of Rubus sp. extract was effective in preventing the increase in reactive species and nitrites levels, as well as the decrease in catalase activity induced by LPS in the cerebral cortex. In the serum, the Rubus sp. extract was effective in preventing the decrease in catalase activity induced by LPS. Treatment with Rubus sp. extract attenuated the increase in acetylcholinesterase activity induced by LPS in the cerebral cortex. Finally, blackberry extract also downregulated IL-1β levels in cerebral cortex. In conclusion, our findings demonstrated that treatment with Rubus sp. exerted antidepressant, antioxidant, anticholinesterase and anti-inflammatory effects in a model of depressive – like behavior induced by LPS in female mice. This highlights Rubus sp . as a potential therapeutic agent for individuals with major depressive disorder. [ABSTRACT FROM AUTHOR]