학술논문
Psidium cattleianum fruit extract prevents systemic alterations in an animal model of type 2 diabetes mellitus: comparison with metformin effects.
Document Type
Article
Author
Cardoso, Juliane De Souza; Cardoso Teixeira, Fernanda; De Mello, Julia Eisenhardt; Soares De Aguiar, Mayara Sandrielly; Souto Oliveira, Pathise; Torchelsen Saraiva, Juliane; Vizzotto, Marcia; Borelli Grecco, Fabiane; Lencina, Claiton Leoneti; Spanevello, Roselia Maria; Tavares, Rejane Giacomelli; Stefanello, Francieli Moro
Source
Subject
*TYPE 2 diabetes
*FRUIT extracts
*ANIMAL models in research
*METFORMIN
*HIGH-fat diet
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Language
ISSN
1354-750X
Abstract
Objective: In this study, we aimed to determine the role of Psidium cattleianum extract (PCE) and compare its effects with those of metformin (Met) in an animal model with type 2 diabetes mellitus (T2DM). Methods: T2DM was induced in rats using a high-fat diet (HFD), followed by a single dose of streptozotocin (STZ). Met and PCE were administered intragastrically once a day throughout the experiment, and their effects on biochemical, inflammatory, oxidative, and histological parameters were evaluated. Results: Met and PCE prevented the increase in serum levels of glucose, total cholesterol (TC), triacylglycerol (TG), very low-density lipoprotein (VLDL) and interleukin-6 (IL-6) induced by T2DM, and restored redox homeostasis in the liver and brain. Met increased the serum levels of anti-inflammatory cytokine and interleukin-10 (IL-10). Furthermore, both treatments restored the liver and pancreas from marked cellular disorganisation, vacuolisation, and necrosis, with PCE being more effective than Met in recovering histological changes. Conclusion: PCE is a promising agent for the prevention of T2DM complications. [ABSTRACT FROM AUTHOR]