부산대학교 도서관

Purpose To compare posture‐induced intraocular pressure (IOP) changes in controls, medically treated, and untreated primary open angle glaucoma (POAG) patients. Methods One eye from each of 20 age‐matched controls, 21 treated and 14 untreated POAG patients was included. IOP was measured with a Perkins tonometer and arterial pressure (AP) with a sphygmomanometer consecutively in the sitting, supine and 20 degrees Trendelenburg positions, allowing for a period of 5 minutes between positions. Differences in IOP and mean AP between the sitting, supine and Trendelenburg positions were calculated. Results Mean±SD sitting IOP was 13.5±1.9 mmHg in the control group, 22.0±4.4 mmHg in the untreated POAG group and 13.5±2.5 mmHg in the treated POAG group (one‐way ANOVA, p<.001). The IOP change from the sitting to supine position was 0.9±1.3 mmHg in the control group, 2.3±1.7 mmHg in the treated POAG group and 3.1±1.9 mmHg in the untreated POAG group (one way ANOVA p<.001). The IOP change from the sitting to the Trendelenburg position was 1.7±1.6 mmHg in the control, 4.2±2.2 mmHg in the treated POAG and 4.3±3.1 mmHg in the untreated POAG groups, respectively (p<.001). Post hoc pairwise comparisons revealed significant differences between each POAG group and controls (p<.01). No difference was observed in IOP changes between treated and untreated POAG patients for the sitting‐to‐supine (p=.14) and the sitting‐to‐Trendelenburg transitions (p=.90). No significant posture‐induced AP change was observed in any group (repeated measures ANOVA p>.1). Conclusion Irrespective of treatment, POAG patients exhibit a bigger posture‐related IOP change compared to controls. This change is bigger when assuming the Trendelenburg position. [ABSTRACT FROM AUTHOR]