부산대학교 도서관

Amlodipine besylate and Losartan Potassium is Cardio vascular agent, calcium channel blocker Amlodipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. There are at least five different types of calcium channels in Homo sapiens: L-, N-, P/Q-, R- and T-type. And Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end organ responses to angiotensin II. Losartan administration results in a decrease in total peripheral resistance (afterload) and cardiac venous return (preload) All of the physiological effects of angiotensin II, including stimulation of release of aldosterone, are antagonized in the presence of losartan. Fast dissolving tablets are solid dosage form that contains medicinal substances and that disintegrate and dissolve rapidly without water (within seconds) when placed on the tongue. Fast dissolving tablets of Amlodipins and Losartan Potassium were prepared by direct compression method using Sodium Starch Glycolate, Ac-Di-Sol, as a super disintegrants, and controlled tablets without any super disintegrant and evaluated for hardness, friability, disintegration time, dissolution time, water absorption ratio and content uniformity. All tablets containing super disintegrates shows release of drug more than 95% within 10 minutes. [ABSTRACT FROM AUTHOR]