부산대학교 도서관

Purpose To investigate the sensitivity and specificity of the stereometric parameters change analyses vs. TCA in early detection of glaucoma progression. Methods 81 patients with POAG were monitored for 4 years: GAT (monthly), SAP (every 6 months), optic disc photographs and HRT3 (yearly). The exclusion criteria were optic disc or retinal pathology that might interfere with the detection of glaucoma progression, TSD >30 and inter‐test variation of RH above 25 μm for all HRT exams. The criterion for structural progression was considered at least 20 adjacent super‐pixels with clinically significant decrease in height (>5%). Results 16 patients of total 81 presented structural progression on TCA. The most useful stereometric parameters for early detection of glaucoma progression were: Rim Area change (sensitivity 100%, specificity 74.2% for a "cut off" value of ‐0.05), C/D Area change (sensitivity 85.7%, specificity 71.5% for a "cut off" value of 0.02), C/D linear change (sensitivity 85.7%, specificity 71.5% for a "cut off" value of 0.02), Rim Volume change (sensitivity 71.4%, specificity 88.8% for a "cut off" value of ‐0.04). RNFL Thickness change (<0) was highly sensitive (82%), but less specific for glaucoma progression (45,2%). The changes of the other stereometric parameters have a limited diagnostic value for early detection of glaucoma progression. Conclusion TCA is a valuable tool for assessing structural progression in glaucoma patients and its inter‐test variability is low. On long‐term run quantitative analysis by stereometric parametres change is also very important. The present study shows that the most relevant parameters to detect progression are RA, C/D Area, Linear C/D and RV. [ABSTRACT FROM AUTHOR]