부산대학교 도서관

Objective: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension.Methods: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls.Results: Syndecan-1 concentrations were lower at 26-27+6 weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia.Conclusion: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia. [ABSTRACT FROM AUTHOR]