학술논문
Changes in pro-oxidant–antioxidant balance after bare metal and drug eluting stent implantation in patients with stable coronary disease
Document Type
Article
Author
Falsoleiman, Homa; Dehghani, Mashalla; Moohebati, Mohsen; Fazlinezhad, Afsoon; Daloee, Mahdi Hassanzadeh; Alamdari, Daryoush Hamidi; Esmaily, Habib Ollah; Parizadeh, Seyyed Mohammad Reza; Tavallaie, Shima; Rahsepar, Amir Ali; Paydar, Roghayeh; Kazemi-Bajestani, Seyyed Mohammad Reza; Pourghadam-Yari, Hossein; Parizad, Parisa Abbasi; Ghayour-Mobarhan, Majid; Ferns, Gordon A.
Source
Subject
*ANTIOXIDANTS
*ANGIOPLASTY
*SURGICAL stents
*CORONARY disease
*HEALTH outcome assessment
*OXIDATIVE stress
*PATIENTS
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Language
ISSN
0009-9120
Abstract
Abstract: Objectives : In this study we aimed to assess the changes in pro-oxidant–antioxidant balance (PAB) after the placement of either a drug-eluting-stent (DES) or bare-metal-stent (BMS) in patients with stable coronary artery disease. Design and methods : Percutaneous coronary interventions (PCI) with either BMS or DES were undertaken for 152 patients (82 in the BMS and 70 in the DES groups respectively). PAB values were measured 24h before and after PCI. Results : Baseline PAB values were 80.68 (64.98–99.37) and 98.86 (64.70–140.62) for BMS and DES group, respectively, which were not significantly different between the 2 groups (P >0.05). Following PCI, median PAB values decreased to 72.10 (61.40–96.13) and 81.40 (54.15–121.90) in BMS and DES groups, respectively. The reduction was significant in both BMS and DES groups (P <0.05). The changes in PAB values were −2.81 (−12.76 to 2.31) for BMS and −2.82 (−29.88 to 8.93) for DES group, which were not significantly different between the 2 groups (P >0.05). Conclusion : We found that the reported difference in clinical outcomes following DES or BMS implantation cannot be attributed to differences in early changes in oxidative stress induction as assessed by changes in PAB values. [Copyright &y& Elsevier]