부산대학교 도서관

This document explores the use of physiologically based pharmacokinetic (PBPK) modeling to study the effects of drugs on pregnant women, lactating women, and neonates. It discusses the limitations of traditional dosing methods and the potential risks of inadequate or harmful drug effects. The document provides examples of successful applications of PBPK modeling, such as predicting drug concentrations in human milk. It emphasizes the need for further research and data to improve these models and better understand the unique physiological characteristics of these populations. The authors stress the importance of systematic searches, data integration, and clinical data in refining these models and promoting evidence-based pharmacotherapy for vulnerable populations. [Extracted from the article]