학술논문
Unified platform for genetic and serological detection of COVID-19 with single-molecule technology.
Document Type
Article
Author
Source
Subject
*COVID-19
*COVID-19 pandemic
*VIRUS diseases
*SARS-CoV-2
*IMMUNOGLOBULIN G
*IMMUNOGLOBULIN M
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Language
ISSN
1932-6203
Abstract
The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients' samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens. [ABSTRACT FROM AUTHOR]