학술논문
RNA polymerase III transcription can be derepressed by oncogenes or mutations that compromise p53 function in tumours and Li-Fraumeni syndrome.
Document Type
Article
Source
Subject
*TUMOR suppressor genes
*P53 antioncogene
*RNA polymerases
TUMOR genetics
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Language
ISSN
0950-9232
Abstract
Presents a study which examined how the ability of tumor suppressor p53 to regulate RNA polymerase (pol) III transcription is influenced by various perturbations that occur in human tumors. Transcriptional activity of pol III in primary fibroblasts of patients that inherit mutant forms of p53; Materials and methods used in the study; Results.