학술논문
Synthesis, structural characterization and preliminary cancer cell line results for polymers derived from reaction of titanocene dichloride and various poly(ethylene glycols).
Document Type
Article
Author
Source
Subject
*ORGANOTITANIUM compounds
*CELL lines
*PANCREATIC cancer
*POLYETHYLENE glycol
*DIMETHYL sulfoxide
*POLYETHERS
*NUCLEAR magnetic resonance
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Language
ISSN
1060-1325
Abstract
We describe the initial synthesis of DMSO and water-soluble titanocene polyethers through reaction of the titanocene dichloride and various poly(ethylene glycols) employing commercially available reactants. Infrared, proton NMR, and MALDI MS results are consistent with the titanocene-containing polyether structure. The materials are polymeric with chain lengths ranging from 1500 to 4. They exhibit good inhibition of a variety of cancer cell lines including two pancreatic cancer cell lines. [ABSTRACT FROM PUBLISHER]