학술논문
Genotypic and phenotypic characterization of Staphylococcus epidermidis causing chronic relapsing prosthetic joint infections.
Document Type
Article
Author
Source
Subject
*ACADEMIC medical centers
*CHROMOSOME banding
*DRUG resistance in microorganisms
*GENES
*HISTOLOGICAL techniques
*INFECTION
*MICROBIAL sensitivity tests
*COMPLICATIONS of prosthesis
*PULSED-field gel electrophoresis
*STAPHYLOCOCCUS
*TOTAL hip replacement
*TOTAL knee replacement
*PHENOTYPES
*DISEASE relapse
*RETROSPECTIVE studies
*SUPERINFECTION
*DATA analysis software
*DESCRIPTIVE statistics
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Language
ISSN
0036-5548
Abstract
Twenty-one isolates of Staphylococcus epidermidis from 9 patients with persistent prosthetic joint infections were analysed by pulsed-field gel electrophoresis and antibiotic susceptibility assays. In 7 of these cases, the S. epidermidis isolate was different from that of the initial episode. In 1 further case, the superinfection was polyclonal. Recurrence, i.e., renewed isolation of a clone identical to that of an initial episode, occurred in 3 cases, 1 of which was in the absence of superinfection. A high degree of antibiotic resistance was demonstrated, including methicillin in 17 of 21 strains. In conclusion, a frequent occurrence of superinfection and a high degree of resistance make management of these infections complex. [ABSTRACT FROM AUTHOR]