학술논문
Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice?
Document Type
Article
Source
Subject
*VITAMIN D metabolism
*BIOMARKERS
*CHOLESTEROL
*ENZYME inhibitors
*TACROLIMUS
*GENETIC polymorphisms
*KIDNEY transplantation
*MEDICAL practice
*OXIDOREDUCTASES
*TRANSPLANTATION of organs, tissues, etc.
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Language
ISSN
0931-041X
Abstract
CYP3A enzymes are involved in the metabolism of calcineurin inhibitor tacrolimus as well as vitamin D. In this review, we summarize the clinical aspects of CYP3A-mediated metabolism of tacrolimus and vitamin D with emphasis on the influence of single-nucleotide polymorphisms on tacrolimus disposition. We describe the utility of 4β hydroxycholesterol as a marker of CYP3A activity. Then, we discuss the possible interaction between calcineurin inhibitors and vitamin D in solid organ transplant recipients. Also, we review other mechanisms which may contribute to side effects of calcineurin inhibitors on bone. Lastly, suggestions for future research and clinical perspectives are discussed. [ABSTRACT FROM AUTHOR]