학술논문
Peculiar immunophenotypic signature in MIS‐C‐affected children.
Document Type
Article
Author
Source
Subject
*COVID-19
*COVID-19 treatment
*AGAMMAGLOBULINEMIA
*
*
Language
ISSN
0905-6157
Abstract
Between April and July 2020, we performed peripheral B lymphocyte immunophenotype in five patients with positive specific IgG against SARS-CoV2, who satisfied WHO preliminary case definition criteria for MIS-C,1 and compared them with eight children affected by COVID-19 and 15 age-matched healthy donors (HD). Immunophenotype studies in COVID-19 patients have demonstrated a peculiar B-cell response with increased plasmablast (PB) frequency.4 Interestingly, the increase in PB is not associated with an augmentation in spike protein-specific IgG titer. Since April 2020, an increasing number of authors have reported a new clinical syndrome related to SARS-COV2 infection in children, characterized by rapidly progressive systemic inflammation with multi-organ dysfunction. [Extracted from the article]