학술논문
Platelet Count After Chemotherapy is a Predictor for Outcome for Ovarian Cancer Patients.
Document Type
Article
Source
Subject
*CANCER chemotherapy
*OVARIAN cancer
*CHEMOTHERAPY complications
*PLATELET count
*DISEASE progression
*HEALTH outcome assessment
OVARIAN cancer patients
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Language
ISSN
0735-7907
Abstract
Elevated platelet count occasionally is associated with gynecologic malignancies. We investigated the level of platelet count in 450 patients with gynecologic tumors. Ovarian cancer patients have increased platelet count associated with the course of treatment and disease progression. In multivariate analysis, the decrease of platelet count less than 25% after chemotherapy was an unfavorable prognostic factor for PFS (HR, 1.948; 95% CI, 1.083-3.505; p = 0.026) and overall survival (HR, 2.093; 95% CI, 1.022-4.287; p = 0.043). An insufficient decrease of the platelet count increased the risk of recurrence. Thus platelet count could be used for monitoring the disease progression and to predict treatment response. [ABSTRACT FROM AUTHOR]