학술논문
Host metabolomic responses in recurrent P. vivax malaria.
Document Type
Article
Author
Yakubu, Michael N.; Mwangi, Victor I.; Netto, Rebeca L. A.; Alecrim, Maria G. C.; Alves, Jessica R. S.; Almeida, Anne C. G.; Santos, Gabriel F.; Lima, Gesiane S.; Machado, Lucas S.; Koolen, Hector H. F.; Guimarães, Tiago P.; Chaves, Andrea R.; Vaz, Boniek G.; Monteiro, Wuelton M.; Costa, Fabio T. M.; Lacerda, Marcus V. G.; Gardinassi, Luiz G.; de Melo, Gisely C.
Source
Subject
*METABOLOMICS
*MALARIA
*VITAMIN B6
*PARASITIC diseases
*METABOLISM
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Language
ISSN
2045-2322
Abstract
Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC–MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. [ABSTRACT FROM AUTHOR]