부산대학교 도서관

The absence of simultaneous OPM-MEG/SEEG recording or comparison with cryogenic MEG (unavailable at the time of recording due to technical issues) prevents proper estimation of OPM-MEG localization accuracy for ictal discharges. In drug-resistant focal epilepsy (DRFE), seizures are infrequent and unpredictable, requiring prolonged recordings to identify the seizure-onset zone (SOZ).[1] Cryogenic magnetoencephalography (MEG) is thus scarcely used for ictal recordings but rather to detect interictal epileptiform discharges (IEDs) and localize the irritative zone (IZ), which may differ from the SOZ.[1] On-scalp MEG based on a new-generation, cryogenic-free magnetic sensors, "optically-pumped magnetometers" (OPM-MEG), allows successful localization of IEDs with higher amplitude and signal-to-noise ratio (SNR) than cryogenic MEG.[2] Although OPM-MEG has clear advantages (i.e., on-scalp recording, increase in SNR, free head movements[3]) over cryogenic MEG to record ictal discharges, no study has demonstrated the ability of OPM-MEG to detect ictal discharges. We report on a 10-year-old boy suffering from DRFE (>5 seizures/day) who underwent on-scalp ictal and interictal video-OPM-MEG recording at rest (1 hour) and during hyperventilation as a seizure activation procedure (3 minutes). [Extracted from the article]