학술논문
Targeting NK-cell checkpoints for cancer immunotherapy.
Document Type
Article
Author
Source
Subject
*CANCER immunotherapy
*KILLER cells
*CELL-mediated cytotoxicity
*MONOCLONAL antibodies
*CYTOKINES
*LIGANDS (Biochemistry)
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Language
ISSN
0952-7915
Abstract
Natural Killer (NK) cells are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells. NK-cell function is regulated by activating and inhibitory surface receptors recognizing their ligands on transformed cells. Modulation of NK numbers and/or function by a variety of agents such as cytokines and monoclonal antibodies may result in enhanced anti-tumor activity. Recombinant cytokines ( i.e. , IL-15 and IL-2), antibodies blocking inhibitory receptors ( i.e. , KIR, NKG2A and TIGIT) and agonists delivering signals via CD137, NKG2D and CD16 stand out as the most suitable opportunities. These agents can be used to potentiate NKcell- mediated antibody-dependent cellular cytotoxicity (ADCC) against antibody-coated tumor cells, offering potential for multiple combinatorial immunotherapy strategies against cancer. [ABSTRACT FROM AUTHOR]