학술논문
Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo.
Document Type
Article
Author
Source
Subject
*GENE therapy
*PLASMIDS
*
Language
ISSN
0969-7128
Abstract
Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated. [ABSTRACT FROM AUTHOR]