학술논문
Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure.
Document Type
Article
Author
Jallow, Sabelle; Wilmshurst, Jo M; Howard, Wayne; Copelyn, Julie; Seakamela, Lerato; Chan, Koon-Wing; Sebunya, Robert; Sibiya, Rosinah; Plessis, Heleen Du; Jacobs, Charlene; Berkowitz, Natacha; Blumberg, Lucille; McCarthy, Kerrigan; Maseti, Elizabeth; Kamupira, Mercy; Dlamini, Nonhlanhla; Gumede, Nicksy; Diop, Ousmane M; Lau, Yu Lung; Moonsamy, Shelina
Source
Subject
*CEREBROSPINAL fluid examination
*AGAMMAGLOBULINEMIA
*AZIDOTHYMIDINE
*HIV
*IMMUNOGLOBULINS
*MAGNETIC resonance imaging
*X-linked genetic disorders
*POLIO
*POLIOMYELITIS vaccines
*ACUTE flaccid paralysis
*DISEASE complications
*DISEASE risk factors
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Language
ISSN
1058-4838
Abstract
Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus. [ABSTRACT FROM AUTHOR]