학술논문
P53 induces the expression of its antagonist p73N, establishing an autoregulatory feedback loop.
Document Type
Article
Author
Source
Subject
*PROTEINS
*PROMOTERS (Genetics)
*HUMAN genetics
*GENETIC transcription
*APOPTOSIS
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Language
ISSN
0950-9232
Abstract
Presents a study which showed that p53 tumor suppressor protein directly activates a second promoter within the human p73 gene, giving rise to enhanced p73N mRNA and protein levels. Prevention of p53-mediated transcriptional activation and apoptosis by p73N; Details of the regulatory feedback loop for the efficient control of p53 activity; Function of p53 in transcription activation and cell death.