학술논문
Clinical Stage III NSCLC Patients Treated with Neoadjuvant Therapy and Surgery: The Prognostic Role of Nodal Characteristics †.
Document Type
Article
Author
Chiappetta, Marco; Tabacco, Diomira; Iaffaldano, Amedeo Giuseppe; Evangelista, Jessica; Congedo, Maria Teresa; Sassorossi, Carolina; Meacci, Elisa; D'Argento, Ettore; Bria, Emilio; Vita, Emanuele; Tortora, Giampaolo; Boldrini, Luca; Charles-Davies, Diepriye; Massaccesi, Mariangela; Martino, Antonella; Mazzarella, Ciro; Valentini, Vincenzo; Margaritora, Stefano; Lococo, Filippo
Source
Subject
*LUNGS
*SURVIVAL analysis (Biometry)
*PROGRESSION-free survival
*NEOADJUVANT chemotherapy
*POSITRON emission tomography computed tomography
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Language
ISSN
2075-1729
Abstract
Results from analyzing this parameter in patients with persistent nodal involvement in our study (N1 + N2) showed that patients with more than six mediastinal lymph nodes presented a better survival rate compared to patients with less than six removed nodes, with the I p i -value close to the statistical significance ( I p i = 0.057). A difference was also observed between the number of resected lymph nodes and pathological N2 or N1 patients, even if it was not statistically significant: 5YOS of 56.1% in N1 vs. 29.7% in N2 ( I p i = 0.144) and 5YOS of 0% in patients with #RN < 6 vs. 56.6% in patients with #RN >= 6 ( I p i = 0.057) (Figure 4). 4. In this context, the lymph node ratio could also be used to identify patients who could benefit from adjuvant treatments, such as postoperative radiotherapy in patients who still have margin for treatment, or they could be selected to continue consolidation chemotherapies postoperatively. Clinical Stage III NSCLC Patients Treated with Neoadjuvant Therapy and Surgery: The Prognostic Role of Nodal Characteristics †. [Extracted from the article]