학술논문
Tetraspanin8 expression predicts an increased metastatic risk and is associated with cancer-related death in human cutaneous melanoma.
Document Type
Article
Author
Berthier-Vergnes, Odile; Barbollat-Boutrand, Laetitia; Pommier, Roxane M.; de la Fouchardière, Arnaud; Combemale, Patrick; Grimont, Maxime; Lopez-Ramirez, Noémie; Caramel, Julie; Dalle, Stéphane; Perrot, Jean-Luc; Gaudy-Marqueste, Caroline; Macagno, Nicolas; Mansard, Sandrine; Bouquet, Fanny; Masse, Ingrid
Source
Subject
*MELANOMA
*MEDICAL ethics
*SURVIVAL rate
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Language
ISSN
1476-4598
Abstract
Tspan8 expression was correlated with the presence of a BRAF mutation in patient melanoma sam... In melanoma cell lines in vitro, we were not able to highlight a possible correlation between I TSPAN8 i mRNA expression and the presence of a BRAF or a NRAS mutation (sup. These results are particularly interesting since it is known that patients bearing thinner melanomas with no deep cutaneous invasion have generally a better survival rate [[15]] but that some thin melanomas (< 0.75 - 1 mm) could acquire some aggressive properties and lead to patient death. However, Tspan8 was more frequently expressed in samples from patients who died during the 5-year period after the melanoma diagnosis than in samples from patients who remained alive, and especially for thin melanomas, inferior to 1 mm (Fig. [Extracted from the article]