부산대학교 도서관

Among the main consequences of polycystic ovary syndrome (PCOS) are menstrual dysfunction, infertility, hyperandrogenism, insulin resistance, and weight gain; in aggravated cases, it can become a risk factor for the development of metabolic syndrome and cardiovascular disease. We hypothesized that green tea can be an option to complement the treatment of PCOS. Thus, this systematic review aims to evaluate the effects of green tea supplementation in women with PCOS. We searched for randomized controlled trials (RCTs) that evaluated women with PCOS who received green tea compared with placebo in electronic databases: MEDLINE via PubMed, EMBASE via Elsevier, Cochrane Library, LILACS via BVS, and Web of Science using the terms: "polycystic ovary syndrome," "green tea," "Camellia sinensis," "epigallocatechin gallate." The outcomes listed in the study protocol were body weight, fasting insulin, body mass index, body fat percentage, daily caloric intake, waist circumference, hip circumference, and waist/hip ratio. Four double-blind RCTs were included, with a total of 169 women: 85 in the green tea group and 84 in the placebo group. We found a significantly lower body weight (kg) for green tea group (mean difference, -2.80; 95% confidence interval, -5.25 to -0.35; P =.03; I ² = 0%; 4 studies, 169 participants, very low-quality evidence). Green tea has potential positive effects for the reduction of weight, and future studies will be needed to confirm the estimated effect size; we reasonably expect this to be an option of adjuvant treatment in PCOS clinical management. Registration number: CRD42021226296. Through database searching, 902 studies on the effects of green tea on polycystic ovary syndrome (PCOS) was identified. After removing duplicates, 861 studies were screened by reading titles and abstracts, with 12 studies selected for full-text reading. Of these, 4 randomized controlled trials met all established inclusion criteria and were included in the systematic review. The total population included 169 women with PCOS, of whom 85 received green tea intervention and 84 received placebo. Of the included studies, 3 were assessed as having a low risk of bias by their methodology. One study presented a high risk of bias, having the same classification for 3 methodological domains evaluated, and 1 domain classified as having "some concerns." For the assessment of body weight reduction, the 4 studies were pooled into a meta-analysis, indicating a significant difference for green tea. CI, confidence interval; MD, mean difference. [Display omitted] [ABSTRACT FROM AUTHOR]