학술논문
Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis.
Document Type
Article
Source
Subject
*CYSTIC fibrosis
*IMMUNOGLOBULIN A
*CYSTIC fibrosis transmembrane conductance regulator
*MUCOCILIARY system
*IMMUNITY
*EPITHELIUM
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Language
ISSN
2073-4409
Abstract
The respiratory epithelium represents the first chemical, immune, and physical barrier against inhaled noxious materials, particularly pathogens in cystic fibrosis. Local mucus thickening, altered mucociliary clearance, and reduced pH due to CFTR protein dysfunction favor bacterial overgrowth and excessive inflammation. We aimed in this review to summarize respiratory mucosal alterations within the epithelium and current knowledge on local immunity linked to immunoglobulin A in patients with cystic fibrosis. [ABSTRACT FROM AUTHOR]