학술논문

Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation.
Document Type
Article
Source
Internal Medicine Journal. Dec2023, Vol. 53 Issue 12, p2162-2174. 13p.
Subject
*ENDOTHELIUM
*CAPILLARY leak syndrome
*ADRENOCORTICAL hormones
*HEMATOPOIETIC stem cell transplantation
*HEPATIC veno-occlusive disease
*POSTERIOR leukoencephalopathy syndrome
*DISEASE management
Language
ISSN
1444-0903
Abstract
Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient‐ and transplant‐specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant‐associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment. [ABSTRACT FROM AUTHOR]