학술논문
CDK13 cooperates with CDK12 to control global RNA polymerase II processivity.
Document Type
Article
Author
Zheng Fan; Devlin, Jennifer R.; Hogg, Simon J.; Doyle, Maria A.; Harrison, Paul F.; Todorovski, Izabela; Cluse, Leonie A.; Knight, Deborah A.; Sandow, Jarrod J.; Gregory, Gareth; Fox, Andrew; Beilharz, Traude H.; Kwiatkowski, Nicholas; Scott, Nichollas E.; Vidakovic, Ana Tufegdzic; Kelly, Gavin P.; Svejstrup, Jesper Q.; Geyer, Matthias; Gray, Nathanael S.; Vervoort, Stephin J.
Source
Subject
*RNA polymerase II
*STREPTAVIDIN
*RNA polymerases
*RAPAMYCIN
*BIOCHEMISTRY
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Language
ISSN
2375-2548
Abstract
The article discusses a study according to which cyclin-dependent kinases (CDKs)13 cooperates with CDK12 to control global RNA polymerase II processivity. It mentions that single inhibition of CDK12 or CDK13 induced transcriptional responses associated with cellular growth signaling pathways and/or DNA damage, with minimal effects on cell viability.