부산대학교 도서관

Malignant neoplasms are today one of the leading causes of death in the world. Their treatment is extremely complex and requires the application of various chemical compounds which leads to disruption of homeostasis in the human body. During a treatment, there is a possibility of complex formation with important bioelements, such as copper, iron, cobalt, manganese, and others in the biological system. This paper presents the results of possible formation of complexes between Fe(II) and Mn(II) ions and capecitabine (IUPAC name: pentyl 1-((2R,3R,4S,5R)-3,4-dihydroxy- 5-methyl-tetra- hydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl carbamate). This chemotherapeutic agent is often used for the treatment of different solid tumors including breast, colon, prostate, liver and gastrointestinal tract carcinoma. Spectroscopic methods (UV/Vis and FT-IR spectroscopy) were used in order to research specific compounds between CPC and metal ions that may be formed in human body under physiological and approximately physiological conditions. In addition, microscopic characterization and comparison of solid samples of capecitabine and products of interactions of CPC as a ligand with Fe(II) and Mn(II) ions have been performed. FT-IR spectra indicate the existence of interaction of these two divalent bio cations with CPC, i.e. their coordination through nitrogen and oxygen atoms of CPC. When UV spectra of pure ligand and model systems M(II)-CPC were compared, similar absorption bands were observed with absorption maxima at the same wavenumbers but lower absorbance values for model systems M(II)-CPC. [ABSTRACT FROM AUTHOR]