학술논문
Evaluation of serum levels of soluble CD4, CD8 and Β2 -microglobulin in visceral human leishmaniasis.
Document Type
Abstract
Author
Source
Subject
*LEISHMANIASIS
*PROTOZOAN diseases
*SERUM
*BLOOD platelet disorders
*IMMUNITY
*PATIENTS
*
*
*
*
*
Language
ISSN
0009-9104
Abstract
The levels of soluble CD4 (sCD4), sCD8 and β2-microglobulin (β2-M) were measured in sera from patients with visceral leishmaniasis during the course of infection. Levels orsCD4, sCD8and β2-M were raised significantly above levels in normal sera and returned to the normal range after recovery. The decrease in the levels of sCD8 was related to a reduction of anaemia, leukopenia and thrombocytopenia. In contrast, sCD4 levels fluctuated during the period of infection. β2-M returned within normal range more rapidly than sCD8 secretion. Our results suggest that T cells are activated during infection, and that it is also possible that the raised levels of these soluble molecules play a role in the impairment of protective immunity. [ABSTRACT FROM AUTHOR]