학술논문
The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients.
Document Type
Article
Author
Source
Subject
*LEISHMANIASIS
*BLOOD plasma
*ANTIVIRAL agents
*PROTOZOAN diseases
*SERUM
*ANTINEOPLASTIC agents
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Language
ISSN
0009-9104
Abstract
Sera from nine Sicilian patients with confirmed visceral leishmaniasis (Leishmtmia donovani infantum; VL). at the moment of the diagnosis, during the course of the disease and after clinical recovery, were analysed for the concentration of soluble IL-2 receptor (sIL-2R). The results show that sIL-2R is a marker of disease activity, since it is in high concentration at the beginning of infection and returns to the normal range following successful chemotherapy. At the same time of serum analysis for sIL-2R, peripheral blood mononuclear cells (PBMC) of VL patients were stimulated with phytohaemagglutinin (PHA) or antigen and supernatant tested for IL-2 and interferon-gamma (IFN-γ) production. Data demonstrate that there is an inverse relation between concentration of IL-2 and IFN-γ in the supernatants and sIL-2R secretion in the sera. [ABSTRACT FROM AUTHOR]