부산대학교 도서관

Introduction/Background: Optical coherence tomography angiography (OCT-A) is a new non-invasive imaging technique for the diagnosis and follow-up of different diseases, that allows a detailed visualization of blood flow in the retina and in the choroid. This study was aimed to analyze the choroidal features of angioid streaks (AS) on OCT-A in order to gather pathogenic insights. Methods: We retrospectively analyzed 28 eyes of 14 subjects (9 males and 5 females, age 57 ± 12 years) affected by AS, with and without choroidal neovascularization (CNV). All patients underwent standard multimodal imaging, including multicolor imaging, infrared reflectance (IR), blue autofluorescence (BAF), fluorescence angiography (FA), spectral-domain (SD)-OCT and OCT-A (AngioplexTM, CIRRUS HD-OCT models 5000, Carl Zeiss Meditec, Inc., Dublin, USA). We studied the features of AS on OCT-A and compared them with the findings of angiography and SD-OCT. Results: A total of 60 angioid streaks were investigated by means of OCT-A. Most of them (50 AS) appeared characterized by choriocapillary rarefaction, corresponding to an hypo-reflective area of the RPE-Bruch's membrane complex on SD-OCT. Five AS were not clearly evident on OCT-A choriocapillary segmentation. Choroidal segmentation was found to be normal in all patients in correspondence of AS. Conclusions: On OCT-A in most cases a rarefaction of the choriocapillary network is evident in correspondence of AS. OCT-A allows confirming in vivo previous histopathology findings of AS. Acknowledgements: The authors have no proprietary, funding, or conflicts of interest to disclose. [ABSTRACT FROM AUTHOR]