학술논문
Outcome of allogeneic stem cell transplant for Fanconi anemia in India.
Document Type
Article
Author
Source
Subject
*FANCONI'S anemia
*STEM cell transplantation
*HEMATOPOIETIC stem cell transplantation
*BONE marrow transplantation
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Language
ISSN
0888-0018
Abstract
This letter to the editor discusses the outcome of allogeneic stem cell transplant (HSCT) for Fanconi Anemia (FA) in India. FA is a rare genetic disease that can lead to bone marrow failure, myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and head and neck malignancies. The study analyzed data from 190 patients who underwent HSCT for FA in India from 1999 to 2019. The results showed that the overall survival rate was 64%, and the event-free survival rate was 62.5%. The study also found that matched related donor transplants had the highest survival rate, and chronic graft-versus-host disease (GVHD) was associated with a higher risk of second malignancy. The authors suggest considering T-cell depletion and the use of bone marrow grafts to reduce the risk of chronic GVHD and associated malignancies. [Extracted from the article]