학술논문
Improving the Diagnosis of Autism Spectrum Disorder in Fragile X Syndrome by Adapting the Social Communication Questionnaire and the Social Responsiveness Scale-2.
Document Type
Article
Author
Source
Subject
*DIAGNOSIS of autism
*TEST validity
*FACTOR analysis
*FRAGILE X syndrome
*RESEARCH methodology
*CLASSIFICATION of mental disorders
*PSYCHOMETRICS
*QUALITY assurance
*QUESTIONNAIRES
*RESEARCH
*RECEIVER operating characteristic curves
*RESEARCH methodology evaluation
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Language
ISSN
0162-3257
Abstract
We carried out a psychometric assessment of the Social Communication Questionnaire (SCQ) and the Social Responsiveness Scale (SRS-2) in fragile X syndrome (FXS), relative to clinician DSM5-based diagnosis of autism spectrum disorder (ASD) in FXS. This was followed by instrument revisions that included: removal of non-discriminating and/or low face validity items for FXS; use of receiver operating characteristic (ROC) curves to determine optimal cut points for the original and revised measures; an exploratory factor analysis to outline subscales better representing ASD in FXS; and creation of a "triple criteria" diagnosis to better delineate ASD subgroups in FXS. These methods improved the sensitivity and/or specificity of the SCQ and SRS-2, but diagnostic accuracy of ASD remains problematic in FXS. [ABSTRACT FROM AUTHOR]