학술논문
Perm1 Protects the Heart From Pressure Overload–Induced Dysfunction by Promoting Oxidative Metabolism.
Document Type
Article
Author
Source
Subject
*WESTERN immunoblotting
*METABOLISM
*ATRIAL natriuretic peptides
*HEART
*BRAIN natriuretic factor
*
*
*
*
Language
ISSN
0009-7322
Abstract
These data suggest that Perm1 protects the heart against pressure overload by restoring oxidative metabolism, and these beneficial effects of Perm1 are mediated through Mic60. Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism Keywords: MICOS; mitochondria; oxidative metabolism; Perm1; pressure overload EN MICOS mitochondria oxidative metabolism Perm1 pressure overload 916 919 4 03/14/23 20230314 NES 230314 Defects in ATP production lead to cardiac dysfunction and heart failure, whereas maintaining appropriate energy production preserves normal heart function and restoring reduced mitochondrial function mitigates heart failure in human and animal models. [Extracted from the article]