학술논문
The role of type I interferons in intestinal infection, homeostasis, and inflammation.
Document Type
Article
Author
Source
Subject
*INTESTINAL infections
*HOMEOSTASIS
*INTERFERONS
*INFLAMMATION
*CYTOKINES
*DISEASE susceptibility
*INFLAMMATORY bowel diseases
*DISEASE progression
*IMMUNOPATHOLOGY
*THERAPEUTICS
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Language
ISSN
0105-2896
Abstract
Type I interferons are a widely expressed family of effector cytokines that promote innate antiviral and antibacterial immunity. Paradoxically, they can also suppress immune responses by driving production of anti-inflammatory cytokines, and dysregulation of these cytokines can contribute to host-mediated immunopathology and disease progression. Recent studies describe their anti-inflammatory role in intestinal inflammation and the locus containing IFNAR, a heterodimeric receptor for the type I interferons has been identified as a susceptibility region for human inflammatory bowel disease. This review focuses on the role of type I IFNs in the intestine in health and disease and their emerging role as immune modulators. Clear understanding of type I IFN-mediated immune responses may provide avenues for fine-tuning existing IFN treatment for infection and intestinal inflammation. [ABSTRACT FROM AUTHOR]