학술논문
Development of a Prediction Model for Short-Term Remission of Patients with Crohn's Disease Treated with Anti-TNF Drugs.
Document Type
Article
Author
Medina-Medina, Rosario; Iglesias-Flores, Eva; Benítez, Jose M.; Marín-Pedrosa, Sandra; Salgueiro-Rodríguez, Isabel; Linares, Clara I.; González-Rubio, Sandra; Soto-Escribano, Pilar; Gros, Beatriz; Rodríguez-Perálvarez, Manuel L.; Cabriada, José L.; Chaparro, María; Gisbert, Javier P.; Chicano-Gálvez, Eduardo; Ortea, Ignacio; Ferrín, Gustavo; García-Sánchez, Valle; Aguilar-Melero, Patricia
Source
Subject
*CROHN'S disease
*PREDICTION models
*CELL junctions
*INFLAMMATORY bowel diseases
*PROTEOMICS
*PROTEIN expression
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Language
ISSN
1661-6596
Abstract
Therapy with anti-tumor necrosis factor (TNF) has dramatically changed the natural history of Crohn's disease (CD). However, these drugs are not without adverse events, and up to 40% of patients could lose efficacy in the long term. We aimed to identify reliable markers of response to anti-TNF drugs in patients with CD. A consecutive cohort of 113 anti-TNF naive patients with CD was stratified according to clinical response as short-term remission (STR) or non-STR (NSTR) at 12 weeks of treatment. We compared the protein expression profiles of plasma samples in a subset of patients from both groups prior to anti-TNF therapy by SWATH proteomics. We identified 18 differentially expressed proteins (p ≤ 0.01, fold change ≥ 2.4) involved in the organization of the cytoskeleton and cell junction, hemostasis/platelet function, carbohydrate metabolism, and immune response as candidate biomarkers of STR. Among them, vinculin was one of the most deregulated proteins (p < 0.001), whose differential expression was confirmed by ELISA (p = 0.054). In the multivariate analysis, plasma vinculin levels along with basal CD Activity Index, corticosteroids induction, and bowel resection were factors predicting NSTR. [ABSTRACT FROM AUTHOR]