학술논문
Breaking the Bottleneck in Anticancer Drug Development: Efficient Utilization of Synthetic Biology.
Document Type
Article
Author
Source
Subject
*SYNTHETIC biology
*DRUG development
*ANTINEOPLASTIC agents
*NATURAL products
*CANCER treatment
*NEW product development
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Language
ISSN
1420-3049
Abstract
Natural products have multifarious bioactivities against bacteria, fungi, viruses, cancers and other diseases due to their diverse structures. Nearly 65% of anticancer drugs are natural products or their derivatives. Thus, natural products play significant roles in clinical cancer therapy. With the development of biosynthetic technologies, an increasing number of natural products have been discovered and developed as candidates for clinical cancer therapy. Here, we aim to summarize the anticancer natural products approved from 1950 to 2021 and discuss their molecular mechanisms. We also describe the available synthetic biology tools and highlight their applications in the development of natural products. [ABSTRACT FROM AUTHOR]