학술논문
Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents.
Document Type
Article
Author
Source
Subject
*PIPERAZINE
*ANTINEOPLASTIC agents
*MOIETIES (Chemistry)
*SUBSTITUTION reactions
*CELL migration
*APOPTOSIS
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*
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Language
ISSN
1747-5198
Abstract
A series of novel quinazoline derivatives containing piperazine analogs are synthesized via substitution reactions with 6,7-disubstituted 4-chloroquinazoline and benzyl piperazine (amido piperazine). Potent antiproliferative activities are observed against A549, HepG2, K562, and PC-3 with N -(3-chlorophenyl)-2-(4-(7-methoxy-6-(3-morpholino-propoxy)quinazoline-4-yl)piperazine-1-yl)acetamidename C9 showing excellent activity. This active derivative was screened for cell migration ability, proliferation effects, and apoptosis against A549 and PC-3 cells, with the result showing biological activity almost equal to that of the control gefitinib. [ABSTRACT FROM AUTHOR]