부산대학교 도서관

This document discusses the unique challenges in identifying biomarkers for psychotic disorders. Biomarkers are observations that provide information about the risk or underlying mechanisms of certain conditions. In the field of psychotic disorders, biomarker research is gaining momentum due to the preference for non-experiential signals in medicine and the assumption that biomarkers are located closer to molecular mechanisms. However, the search for optimal biomarkers in psychotic disorders has been challenging, and biomarkers that are decisive for clinical prediction have not yet been identified. There are significant knowledge gaps between different levels of analysis, and there is a need for biomarkers that are more proximal to key pathophysiological processes. The document also highlights the criteria for optimal biomarkers, which include being proximal to key processes, having well-defined links to higher- and lower-level components, being portable and low-burden, and having predictive capacity for the clinical course of the disorder. Overall, further research is needed to better understand and identify biomarkers for psychotic disorders. [Extracted from the article]