부산대학교 도서관

Several studies have demonstrated that nasal challenges can induce reflex responses in the respiratory system. Some authors have described bronchoconstriction and modification of the pattern of breathing following nasal challenges by irritants and cold air. We propose to determine the effect of nasal stimulation with cold dry air on airway mucosal blood flow (Q aw ) in the proximal tracheal bronchial tree of healthy humans. Nine healthy subjects participated in the study. Baseline measurement Q aw , nasal airway resistance (NAR) and airway caliber by specific airways conductance (SG aw ) were followed by nasal challenge with cold dry air. Q aw , NAR and Sg aw were determined after the challenge. In those subjects in which a significant decline in Q aw was recorded the protocol was repeated after pretreatment with nasal anesthesia using topical lidocaine. Cold dry air challenge produced a significant decrease in mean Q aw for the nine subjects and this response was abolished by pretreatment with nasal anesthesia using topical lidocaine. There was no significant change in Sg aw and NAR after the challenge and topical lidocaine anesthesia. Our data indicates that nasal stimulation with cold dry air leads to a reduction in Q aw and that this effect may be mediated by a nasal reflex. [ABSTRACT FROM AUTHOR]