학술논문
Discovery of a potent and selective agonist of the prostaglandin EP4 receptor
Document Type
Article
Author
Source
Subject
*LACTAMS
*PROSTAGLANDINS
*
Language
ISSN
0960-894X
Abstract
Analogues of PGE2 wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP4 receptor. An optimized compound (19a) shows high potency and agonist efficacy at the EP4 receptor and is highly selective over the other seven known prostaglandin receptors. [Copyright &y& Elsevier]