학술논문
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
Document Type
Article
Author
Lynch, Kevin R.; O'Neill, Gary P.; Liu, Qingyun; Im, Dong-Soon; Sawyer, Nicole; Metters, Kathleen M.; Coulombe, Nathalie; Abramovitz, Mark; Figueroa, David J.; Zeng, Zhizhen; Connolly, Brett M.; Bai, Chang; Austin, Christopher P.; Chateauneuf, Anne; Stocco, Rino; Greig, Gillian M.; Kargman, Stacia; Hooks, Shelley B.; Hosfield, Elizabeth; William Jr., David L.
Source
Subject
*ASTHMA
*CELL receptors
*CHEMICAL inhibitors
*BRONCHI
*PATHOLOGICAL physiology
*PHYSIOLOGY
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Language
ISSN
0028-0836
Abstract
Presents research which described the functional activation of the CysLT1 receptor by leukotrine D4 (LTD4) and leukotrine C4 (LTC4). Role of the cysteinyl leukotrines in human bronchial asthma; Importance of CysLT1-selective antagonists in the treatment of asthma; Previous biochemical characterization of CysLT1 antagonists; Detection of CysLT1-receptor messenger RNA in spleen and lung; Mapping of the CysLT1-receptor gene to the X chromosome.