학술논문
Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.
Document Type
Article
Author
Charbonneau, Mark R.; O’Donnell, David; Blanton, Laura V.; Totten, Sarah M.; Davis, Jasmine C.C.; Barratt, Michael J.; Cheng, Jiye; Guruge, Janaki; Talcott, Michael; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; Wu, Chao; Struckmeyer, Tedd; Barile, Daniela; Mangani, Charles; Jorgensen, Josh; Fan, Yue-mei; Maleta, Kenneth; Dewey, Kathryn G.
Source
Subject
*SIALYLOLIGOSACCHARIDES
*MALNUTRITION in infants
*HUMAN microbiota
*PUERPERIUM
*MALAWIANS
*GROWTH of children
*GERMFREE animals
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Language
ISSN
0092-8674
Abstract
Summary Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion. PaperClip [ABSTRACT FROM AUTHOR]