학술논문
Distinct and mutually exclusive Ca2+ flux‐ and adenylyl cyclase‐inducing gene expression profiles of G‐protein‐coupled receptors on human antigen‐specific B cells.
Document Type
Article
Author
Source
Subject
*B cells
*GENE expression profiling
*REGULATORY B cells
*HISTAMINE receptors
*CELL physiology
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Language
ISSN
0105-4538
Abstract
This article explores the expression profiles of histamine receptors (HRs) and other G-protein-coupled receptors (GPCRs) in B cell clones. The study found that HRH1 and HRH2 genes exhibit mutually exclusive expression patterns in B cells, with HRH1+/HRH2- B cell clones promoting a Th1 response and increased antigen-specific IgE, while HRH1-/HRH2+ B cell clones suppress Th2 cytokines and induce tolerance. The analysis also identified differentially expressed GPCRs associated with Ca2+ and cAMP signaling pathways, suggesting that co-expressed genes may play important regulatory roles in B cell function. The authors declare no conflict of interest. [Extracted from the article]