학술논문
Neurobehavioral deficits of epidermal growth factor-overexpressing transgenic mice: Impact on dopamine metabolism.
Document Type
Article
Author
Source
Subject
*NEUROBEHAVIORAL disorders
*EPIDERMAL growth factor genetics
*GENE expression
*DOPAMINE regulation
*ANIMAL models in research
*SCHIZOPHRENIA
*ALLERGIES
*COCAINE
*LABORATORY mice
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Language
ISSN
0304-3940
Abstract
Highlights: [•] We established the transgenic mice overexpressing EGF. [•] EGF-transgenic mice exhibited the behavioral deficits relevant to schizophrenia. [•] EGF-transgenic mice were hypersensitive to repeated cocaine administration. [•] Overexpression of EGF is associated with altered dopamine metabolism in a region-specific manner. [ABSTRACT FROM AUTHOR]