학술논문
Extracorporeal Membrane Oxygenation–Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy.
Document Type
Article
Author
Source
Subject
*GLYCOSYLATED hemoglobin
*PNEUMONIA
*BURKHOLDERIA infections
*MELIOIDOSIS
*GENETIC mutation
*GENETICS
*BURKHOLDERIA
*INFLAMMATION
*EXTRACORPOREAL membrane oxygenation
*APOPTOSIS
*INTERFERONS
*BIOTHERAPY
*TREATMENT effectiveness
*CASPASES
*IMMUNOTHERAPY
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
1058-4838
Abstract
We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome. [ABSTRACT FROM AUTHOR]