학술논문
Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression.
Document Type
Article
Author
Rocha, Andréa Livia; de Lima, Tanes Imamura; de Souza, Gerson Profeta; Corrêa, Renan Oliveira; Ferrucci, Danilo Lopes; Rodrigues, Bruno; Lopes-Ramos, Camila; Nilsson, Daniel; Knittel, Thiago Leite; Castro, Pollyana Ribeiro; Fernandes, Mariane Font; Santos Martins, Flaviano dos; Parmigiani, Raphael Bessa; Silveira, Leonardo Reis; Carvalho, Hernandes F.; Auwerx, Johan; Vinolo, Marco Aurélio R.; Boucher, Jeremie; Mori, Marcelo A.
Source
Subject
*ADIPOGENESIS
*GUT microbiome
*ADIPOSE tissues
*PEROXISOME proliferator-activated receptors
*MICRORNA
*LIFE sciences
*METABOLISM
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Language
ISSN
2375-2548
Abstract
The article focuses on a study which examined the role of enoxacin in inducing oxidative metabolism and counteracting obesity in adipose tissue and skeletal muscle in miRNA-mediated regulation. Findings of the study contributes to the elucidation of the metabolic effects of fluoroquinolones and acts as proof of principle for the development of therapies aimed at miRNA processing pathway in addressing obesity. Results of the study are discussed. Materials and methods used are described.